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从迷幻中获得的抗菌化合物psilocybin的表征和鉴定

Balakrishnan Karthiyayini¹, Nalliah Nithya Kalyani¹, Balakrishnan Gowdhami²

¹Department of Microbiology, Bharathidasan University, Tiruchirappalli, Tamil Nadu India.

Indian journal of microbiology

|July 14, 2025

概括

在迷幻中发现的psilocybin,对细菌和真菌表现出抗菌性质. 这项研究表明psilocybin.

科学领域:

药理学药理学是指药理学的学科.
菌类学菌类学是指菌类学.
自然产品化学化学

背景情况:

精神中的精神活性化合物psilocybin具有潜在的治疗用途.
传统的用途和新兴的研究强调了psilocybin在心理健康中的治疗应用.
西的抗菌潜力在很大程度上仍未被探索.

研究的目的:

从泰米尔纳德邦Kodaikanal发现的中提取和识别psilocybin. 在泰米尔纳德邦Kodaikanal发现的中提取和识别psilocybin.
评估提取的psilocybin对各种细菌和真菌病原体的抗菌活性.
探索psilocybin作为一种新型抗菌药物开发的基础的潜力.

主要方法:

收集和溶剂提取迷幻.
使用高性能薄层染色学 (HPTLC) 和液体染色学-质谱学 (LC-MS) 识别和量化罗素.
使用井扩散方法进行抗菌活性评估,并确定最小抑制度 (MIC).

主要成果:

西成功提取和鉴定,其Rf值为0.73和0.77.
赛洛西宾显示出针对 Staphylococcus epidermidis,Pseudomonas aeruginosa,Candida tropicalis 和 Trichophyton rubrum 的显著抗菌活性.
细菌病原体的最小抑制度 (MIC) 为12.5μg/ml,而真菌病原体的最小抑制度为6.25μg/ml.

结论:

西对一系列细菌和真菌菌株具有显著的抗微生物特性.
这些发现支持了psilocybin作为一种用于开发新抗菌剂的化合物的潜力.
需要进一步的体内研究来评估潜在药物开发的疗效和毒性.

关键词:

最低抑制度的最小抑制度这种植物是Psilocybe cubensis.这种药物是psilocybin.迷幻是一种迷幻的.

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