从人类iPSCs中提取和培养丰富的Phrenic-Like运动神经元

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Updated: Sep 15, 2025

Conversion of Human Induced Pluripotent Stem Cells iPSCs into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors
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Louise Thiry1, Julien Sirois2, Thomas M Durcan1,2

  • 1Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada.

Bio-protocol
|July 14, 2025
PubMed
概括

研究人员开发了一种协议,以产生人类诱导的多能干细胞衍生动神经元 (hiPSC-phMNs),用于研究呼吸系统运动神经元疾病,如ALS. 这种可复制的方法为了解性运动神经元退化提供了一个新的模型.

关键词:
这就是ALS.基于FACS的细胞分类人类的 iPSC 是人类的.运动神经元疾病建模模型运动神经元替代疗法神经元的运动神经元呼吸机运动神经元 呼吸机运动神经元从iPSC衍生的运动神经元.

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