相关实验视频
Updated: Sep 15, 2025

11:19
Oral Biofilm Formation on Different Materials for Dental Implants
Published on: June 24, 2018
11.6K
研究表面修改牙植入物的抗菌特性
Jeeth Rai1, Anju N Kilari2, Himanshi Sachdev2
1Department of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Sangli, Maharashtra, India.
Journal of pharmacy & bioallied sciences
|July 14, 2025
概括
与未经修改或氧化涂层植入物相比,涂层银纳米颗粒的牙植入物对口腔病原体具有优越的抗菌活性. 这种表面修饰提供了一种有前途的策略,可以对抗周植入炎,并提高牙植入成功率.
科学领域:
- 生物材料科学 生物材料科学
- 牙科植入物学 牙科植入物学
- 纳米技术 纳米技术
背景情况:
- 牙周植入炎是恢复性牙科的一个重大挑战,它是由牙科植入物上的细菌殖民引起的.
- 植入物的表面修饰是一个有希望的策略,可以赋予抗菌性质并改善长期结果.
- 这项研究调查了表面修饰牙植入物对常见口腔病原体的抗菌疗效.
研究的目的:
- 评估和比较未经修改的牙植入物,银纳米颗粒涂层植入物和氧化纳米颗粒涂层植入物的抗菌疗效.
- 评估这些表面修饰对关键口腔病原体Streptococcus mutans和Porphyromonas gingivalis的有效性.
主要方法:
- 三十个牙科植入物被分为三个组:未经修改 (A组),银纳米颗粒涂层 (B组) 和氧化纳米颗粒涂层 (C组).
- 在48小时的潜伏期后,使用甲扩散试验和殖民地形成单位 (CFU) 计数来评估抗菌活性.
- 使用ANOVA进行统计分析,显著程度为P<0.05.
主要成果:
- 覆盖银纳米颗粒的植入物 (B组) 显示出明显更高的抗微生物活性,对两种S. 变种 和 P. 与A组和C组相比,具有更大的抑制区和更大的CFU减少 (P<0.05).
- 涂有氧化纳米颗粒的植入物 (C组) 显示出中度的抗菌活性,性能优于未经修改的植入物 (A组).
- 未经修改的植入物 (A组) 显示出最小的抗菌作用.
结论:
- 牙植入物的表面修饰,特别是使用银纳米颗粒,显著增强了它们的抗菌特性.
- 抗菌涂层代表了一种可行的策略,可以减少周植入炎,并提高牙科植入物的成功率.
- 需要进一步的体内研究来证实这些发现在临床环境中.
相关概念视频
Bacterial Signaling
34.3K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
34.3K
Surface Membrane Barriers
1.5K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.5K
Antimicrobial Proteins
5.8K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
5.8K
Antimicrobial Effectiveness
167
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
167
Biofilms
284
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
284

