多基因风险得分和大脑结构都对儿童时期的外化行为有所贡献 - - 一项青少年大脑和认知发展 (ABCD) 队列研究
Jalmar Teeuw1, Nina Roth Mota2,3, Marieke Klein4,2,3
1Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Neuroscience applied
|July 14, 2025
概括
遗传和大脑变异与儿童的外部化行为有关. 虽然这些因素解释了一些变化,但这些行为的大多数原因仍然未知,这表明环境影响是关键因素.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 以违反社会规范为特征的外部化行为,可以导致有害的结果.
- 早期预测这些行为对于干预和预防反社会行为至关重要.
- 这些行为是遗传的,与大脑结构有关,大脑结构也受到遗传的影响.
研究的目的:
- 调查基因变异,大脑结构和儿童外部化行为之间的关联.
- 评估大脑结构在遗传风险和外部化行为之间的关系中的潜在调解作用.
主要方法:
- 利用了来自青少年大脑认知发展 (ABCD) 队列的11,878名儿童 (9-10岁) 的数据.
- 测量了各种行为特征的外部化行为 (儿童行为检查清单),大脑体积/完整性 (MRI) 和多基因风险评分 (PRS).
- 在150名青少年 (12-21岁) 的独立队列中验证的发现.
主要成果:
- 减少总和灰质体积与增加的外部化行为相关.
- 对于与改变皮层和皮下灰质,以及白质体积/完整性相关的外部化行为,PRS更高.
- 综合遗传,大脑和社会人口因素解释了多达11.9%的行为变化;皮质灰质介导ADHD+DBD PRS协会.
结论:
- 遗传和大脑结构变异与外部化行为有关,但解释了很小比例的变异.
- 在外部化行为中,个体差异的很大一部分仍然无法解释,这突显了环境因素和大脑功能的潜在作用.
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