治疗耐药精神分裂症的生物标志物:系统性审查
Claudia Pisanu1, Giovanni Severino1, Alessandra Minelli2,3
1Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
Neuroscience applied
|July 14, 2025
概括
确定耐治疗精神分裂症 (TRS) 的可靠生物标志物至关重要. 研究表明,TRS具有显著的遗传性,炎症和细胞因子失衡是关键途径.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 耐治疗精神分裂症 (TRS) 会导致严重的残疾和社会经济成本.
- 目前对TRS的治疗指南涉及在克洛扎宾之前的经验试验,延迟有效治疗.
- 预测性生物标记可以使TRS的早期和更有效的管理成为可能.
研究的目的:
- 系统地审查关于治疗耐药精神分裂症的外围生物标记物的现有文献.
- 确定有前途的生物标志物来预测TRS风险并指导早期治疗.
主要方法:
- 在PubMed,Scopus和Web of Science数据库中进行系统的文献搜索.
- 包括75篇研究遗传,蛋白质,代谢物,RNA,甲基化和肠道微生物群标记物的文章.
- 分析研究设计,包括全基因组和候选基因方法.
主要成果:
- 遗传标记是最常被调查的 (42项研究).
- 还探索了蛋白质/代谢物标记 (23项研究),对RNA,甲基化或微生物群的研究较少.
- 研究定义和样本大小的显著异质性挑战了生物标志物的阐明.
- 现有数据表明TRS的遗传性很大,并涉及炎症和细胞因子失衡.
结论:
- 由于研究异质性,对TRS的外围生物标志物很难确定.
- 遗传因素和炎症途径,包括细胞因子失衡,是TRS生物标志物研究的有前途领域.
- 需要进一步进行大规模的多原子研究,以验证TRS早期检测和管理的潜在生物标志物.
相关概念视频
01:26Psychosis: Goals of Pharmacotherapy
212
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
212
01:29Biological Causes of Schizophrenia
151
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
151
01:28Psychosis and Antipsychotic Drugs: Overview
463
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
463
01:28Drug Therapy
105
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
105
01:29Psychological and Sociocultural Causes of Schizophrenia
192
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
192
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
993
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
993