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在固体瘤中,综合系统性免疫-炎症指数 (SII) 和预后营养指数 (PNI) 的预后值

Yan Zhang¹, Min Tang¹, Qian-Hui Gu¹

¹Department of Oncology & Radiotherapy, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, 215300, People's Republic of China.

Cancer management and research

|July 14, 2025

概括

高的全身免疫炎症指数 (SII) 和低的预后营养指数 (PNI) 预测了更糟糕的癌症结果. 患有高SII和低PNI的患者面临最差的生存率,突出了他们的预后价值.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
营养科学营养科学

背景情况:

炎症和营养状况对于癌症的发展和进展至关重要.
系统性免疫炎症指数 (SII) 和预后营养指数 (PNI) 是癌症的预后标志物.
评估治疗前的SII和PNI可以预测各种癌症类型的患者结果.

研究的目的:

评估治疗前SII和PNI对癌症患者预后的预测价值.
在预测结果时确定SII和PNI的最佳切割值.
确定高SII和低PNI对整体存活时间的综合影响.

主要方法:

对508例癌症病例 (2013年6月 - 2022年6月) 的回顾性分析.
从外周血液样本计算治疗前的SII和PNI.
使用接收器运行特征 (ROC) 分析确定截止值.
与临床病理因素的关联分析和使用考克斯回归和卡普兰-梅尔方法的预后.

主要成果:

预处理前最优的截止值被确定为SII = 792.0和PNI = 49.825.
较高的SII和较低的PNI与更糟糕的患者预后有关.
患有高SII和低PNI的患者表现出最低的整体存活率 (OS) (p < 0.001).
多变量分析证实了瘤阶段,BMI,SII和AGR作为OS的独立预后标志物.

结论:

治疗前SII升高是癌症患者显著的独立预后因素.
高SII和低PNI的组合表明预后最差.
这些炎症和营养标志物为癌症患者的治疗结果提供了宝贵的见解.

关键词:

预后预后预后预后营养指数的预后.固体瘤是一个固体瘤.系统性免疫-炎症指数

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