先天性毒素菌症:在西西里东部的一项观察性回顾性研究
Maria Teresa Garozzo1, Rosaria Garozzo2, Pasqua Betta3
1Unit of Pediatrics and Pediatric Emergency, Cannizzaro Hospital, Catania, Italy.
Frontiers in pediatrics
|July 14, 2025
概括
在怀孕后期,母体感染时,先天性毒素菌 (CT) 传播的风险会增加. 产前治疗显著减少CT传播,但长期结果需要进一步研究.
科学领域:
- 医学研究 医学研究
- 传染病 传染病 传染病
- 孕产妇和胎儿的医学
背景情况:
- 怀孕期间的主要*Toxoplasma gondii* (T. gondii*) 感染对胎儿和新生儿构成严重风险,包括流产和先天性疾病.
- 先天性毒素菌症 (CT) 可以导致显著的神经眼科并发症.
研究的目的:
- 为了评估新生儿中CT的发生率.
- 评估CT的婴儿的神经,眼科和听觉后果.
- 检查CT感染率,母亲血清转换时的妊娠年龄,产前治疗和产后结果之间的相关性.
主要方法:
- 在意大利卡塔尼亚研究了一组220名怀疑在2000年至2021年间患有CT的新生儿.
- 产前查发现了98.6%的孕产妇感染.
- 收集的数据包括妊娠史,新生儿临床数据和后续评估.
主要成果:
- 母婴传播 (MTCT) 发生在19.2%的病例中,可供随访.
- 随着母亲血清转换时的妊娠年龄,MTCT的发病率显著增加 (第一季度为5%,第二季度为23%,第三季度为63%).
- 在28天以上的产前治疗与显著较低的MTCT率 (11.8%与28.6%) 相关.
- 在29名感染新生儿中,58.6%的新生儿有症状,有神经和眼科症状.
- 血清转换时的妊娠年龄与临床症状或后续症状的存在之间没有明显的相关性.
结论:
- 产前查是有效的识别新生儿的CT风险.
- 结果与MTCT率的文献一致,但在症状病例相关性方面有所不同.
- 需要进一步的研究来了解影响CT疾病进展和长期结果的因素.
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