由于嵌入的球形流体化,增强了细胞外矩阵重塑
Tao Zhang1, Shabeeb Ameen2, Sounok Ghosh2
1School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
New journal of physics
|July 14, 2025
概括
我们开发了一个计算模型来研究瘤球体如何入侵纤维环境. 球状物质和纤维网络的刚性极大地影响了入侵动态和纤维重塑,揭示了关键的生物物理机制.
科学领域:
- 生物物理学的生物物理.
- 计算生物学 计算生物学
- 癌症研究 癌症研究
背景情况:
- 瘤入侵是一个复杂的生物物理过程,对癌症转移至关重要.
- 在纤维环境中研究瘤球体,如原蛋白,为研究入侵机制提供了体外模型.
研究的目的:
- 开发一个计算模型,预测瘤入侵的新机制.
- 探索球状体形学,光纤网络刚性和入侵动态之间的相互作用.
主要方法:
- 在光纤网络中开发了一个球体的3D计算顶点模型.
- 模拟细胞作为可变形的多面体机械合到一个活跃的光纤网络.
- 调整球状体形学和光纤网络度以观察重塑效应.
主要成果:
- 球状体质学显著影响纤维网络的改造,流体状球状体显示出更大的密度和半径纤维对齐在中间度.
- 细胞运动驱动球形形状的波动,创造反循环,重塑光纤网络.
- 球形和光纤网络之间的最佳机械互惠性发生在特定的中间刚度范围内.
结论:
- 发现了复杂的形态机械相互作用,控制了瘤球状入侵.
- 球形收缩强度和形状波动都在入侵前阶段至关重要.
- 该研究量化了瘤入侵期间最佳球状纤维网络相互作用的条件.
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