用高剂量阿弗利伯塞普特治疗的结果和手术技术
Ahmad M Mansour1,2, Luiz H Lima3, Maurizio Battaglia Parodi4
1Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
Journal of vitreoretinal diseases
|July 14, 2025
概括
这项研究提出了一种具有成本效益的方法,用于使用可用的配方提供高剂量的aflibercept,显示显著的视觉效益和最小的副作用,如增加眼内压力 (IOP). 当标准高剂量aflibercept无法获得时,这种方法提供了一个可行的替代方案.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 高剂量的aflibercept是各种视网膜疾病的关键治疗方法.
- 高剂量的aflibercept的可获得性和成本可能是患者的限制因素.
- 以前的aflibercept配方需要特定的输送方法.
研究的目的:
- 评估一种用于高剂量aflibercept的替代方法.
- 评估使用预填注射器,瓶子或混合配方的安全性和有效性.
- 为了确定对视敏度和眼内压力 (IOP) 的影响.
主要方法:
- 一项前性试点研究涉及32只眼睛,这些眼睛患有诸如新血管与年龄相关的黄斑变性和视网膜静脉封闭等疾病.
- 一个修改后的治疗方案包括体注射,然后注射各种体积的aflibercept或ziv-aflibercept.
- 监测了短期的安全性,视力增益 (logMAR) 和内视力变化.
主要成果:
- 平均1.7个高剂量注射在4.1个月内进行.
- 最好的眼镜校正视力从基线 (1.35 ± 0.71) 显著改善到最终随访时的0.57 ± 0.43 (P < .001).
- 注射后1分钟 (P = .58) 观察到IOP (0.43 ± 4.26 mm Hg) 的微小增加,在6.3%的眼睛中出现轻微的药物反流.
结论:
- 一种可访问且具有成本效益的aflibercept疗法可以实现精确的高剂量输送.
- 这种替代方法表明药物反流量最小,内压力立即增加最小.
- 描述的方法显示了短期临床疗效的潜力,当标准的高剂量aflibercept无法获得或负担不起时.
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