与癌症相关的纤维细胞:异质性,癌症发病性和治疗点
Yutao Li1,2,3,4, Qingyun Liu1,2,3, Xilin Jing1,2,3,4
1Department of Thoracic Surgery Peking University People's Hospital Beijing China.
MedComm
|July 14, 2025
概括
癌症相关纤维细胞 (CAF) 是多样化的细胞,可以促进或抑制瘤生长. 了解CAF亚型是开发有针对性的治疗方法的关键,这些疗法可以破坏瘤-肌瘤共同进化并克服耐药性.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 瘤微环境研究 研究
背景情况:
- 癌症相关纤维细胞 (CAFs) 是瘤微环境 (TME) 中的关键 stromal 调节者,影响瘤进展,转移和治疗抵抗.
- 最近的单细胞多组学和空间转录学揭示了不同的CAF亚型,其作用取决于环境,能够促进免疫抑制或抑制瘤生长.
- CAF的功能双重性对开发有效的治疗策略提出了挑战.
研究的目的:
- 根据来源,生物标志物和TME特定功能的基础上系统地分类CAF亚型.
- 审查CAFs在化学抵抗,茎状维护和免疫抑制利基形成中的作用.
- 评估针对CAF及其信号通路的新兴治疗策略.
主要方法:
- 对CAF亚型进行系统审查和分类.
- 分析化学抵抗,干性和免疫抑制中的作用.
- 评估新兴的治疗策略,包括选择性消耗,表观遗传重编程和途径抑制.
主要成果:
- 识别了具有独特分子特征和空间分布的保存CAF亚型.
- 强调CAFs促进免疫抑制或抑制瘤生长的双重能力.
- 评估了向方法,如FAP+CAF耗尽和CXCL12/CXCR4抑制.
结论:
- 开发特定亚型的生物标志物和精确的 stromal 疗法对于破坏瘤-stroma 同进化至关重要.
- 空间多组学驱动的组合疗法,例如将CAF向与免疫检查点抑制剂相结合,提供了克服微环境驱动抗性的策略.
- 本综述为将CAF生物学与临床创新的转化进展相结合提供了路线图.
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