假设的表观遗传调节机制与生产,尸体和牛肉质量特征有关,在Nelore牛群中
Juliana Afonso1,2, Woo Jun Shim2,3, Tainã Figueiredo Cardoso1
1Animal Biotechnology Group, Embrapa Pecuária Sudeste, São Carlos, São Paulo, Brazil.
Frontiers in genetics
|July 14, 2025
概括
这项研究确定了Nelore牛的表观遗传学调节的关键基因 (DRG),揭示了影响牛肉生产和肉质特征的新型转录因子 (TF) 和辅因子 (TcoF).
科学领域:
- 动物遗传学动物遗传学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 牛肉生产 牛肉生产
背景情况:
- 表观遗传机制影响复杂的特征,如牛肉生产,尸体和肉质.
- 环境因素动态塑造表观遗传状态,需要有效的检测方法.
- 有限的研究和高成本阻碍了对牲畜进行全面的表观遗传分析.
研究的目的:
- 在Nelore牛中确定与生产,尸体和肉质特征相关的候选调节基因.
- 描述可能通过表观遗传机制调节的 Nelore 牛肌肉中的基因.
- 探索新的表观遗传调节剂,以改善牛肉牛的特征.
主要方法:
- 使用TRIAGE和排序产品分析在基因中识别不协调调节的基因 (DRG).
- 作为牛转录因子 (TF) 或辅因子 (TcoFs) 的DRG的研究.
- 在DRG中对SNP与生产和质量特征的关联测试,使用公开的ATAC-Seq和ChIP-Seq数据.
主要成果:
- 确定了51个DRG,其中26个被证实是牛的TF,与各种特征相关.
- 发现SNP与合利诺基酸 (CLA) 和背部脂肪厚度 (BFT) 的关联,分别与PITX2和BTNL9 DRGs相关.
- 13个DRG在至少一个特征上的监管影响已被证明,突出显示LBX1和HOXC10作为关键候选者.
结论:
- 表观遗传调节涉及DRGs,差异表达基因和生产/质量特征之间的复杂关系.
- LBX1和HOXC10是特征调节的有希望的候选基因,它们本身也受到表观遗传控制.
- 这项研究为利用表观遗传见解来提高肉牛养殖和品质提供了基础.
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