接受放射治疗的乳腺癌患者的抑郁和焦虑:一项纵向研究
Shi-Jia Wang1, Xin Feng1, Wei Zhang1
1State Key Laboratory of Molecular Oncology and Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Therapeutic advances in medical oncology
|July 14, 2025
概括
在接受放射治疗 (RT) 的乳腺癌患者中,抑郁和焦虑是常见的,但治疗后六个月的水平显著下降. 识别高风险个体对于及时干预和改善患者结果至关重要.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 辐射疗法 辐射疗法
背景情况:
- 乳腺癌患者经常经历抑郁和焦虑.
- 放射治疗后对这些心理健康状况的前性研究有限.
研究的目的:
- 评估从放射治疗前 (T0) 到放射治疗后 (RT后) 六个月的抑郁和焦虑的患病率和变化.
- 确定患有抑郁症和焦虑症的风险因素,并在这个患者群体中随着时间的推移发展和维持抑郁症和焦虑症.
主要方法:
- 一项前性纵向观察性研究,涉及中国504名乳腺癌患者 (2022年8月至2023年8月).
- 使用了抑郁症和一般性焦虑障碍患者健康调查问卷和焦虑度量表,测量在T0和RT后六个月.
- 使用后勤回归和通用估计方程来分析患病率,变化和风险因素.
主要成果:
- 抑郁症的患病率从T0的37.3%降至RT后六个月的28.4%;焦虑症从26.0%降至20.3%.
- 基线抑郁/焦虑的危险因素包括家族癌症史,抗HER2治疗,绝经前状态,低收入和绝经症状.
- 随着时间的推移,与更高抑郁症相关的因素包括抗HER2疗法,低个人收入和农村生活;随着时间的推移,更高的焦虑与家庭收入低和更年期症状有关.
结论:
- 在接受放射治疗的乳腺癌患者中,抑郁和焦虑很普遍,但治疗后六个月显著下降.
- 建议定期对抑郁和焦虑进行查,特别是对于那些根据已确定的因素被确定为高风险患者.
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