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Updated: Sep 15, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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局部BET PROTACs用于肺部局部受限蛋白质降解

Martin Hemmerling1, Jianming Liu2, Antonio Piras3

  • 1Medicinal Chemistry, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca Gothenburg Sweden martin.hemmerling@astrazeneca.com.

RSC medicinal chemistry
|July 14, 2025
PubMed
概括

这项研究探讨了吸入型蛋白质溶解向奇默体 (PROTACs),重点是传递参数,并引入了新的吸入型原体和额外终端域 (BET) PROTACs,用于体外和体内表征.

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