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甲状腺相关眼科医疗患者视觉通路中的白质结构变化:免费水和多扩散成像研究

Jiaqi Yao^1,2, Xinjian Lu³, Jingxu Ma¹

¹Department of Radiology, The Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.

Frontiers in neurology

|July 14, 2025

概括

自由水 (FW) 和神经元导向分散和密度成像 (NODDI) 显示了甲状腺相关眼病 (TAO) 患者的白质微观结构变化,与心理健康指标相关.

科学领域:

神经成像是一种神经成像.
眼科医生眼科眼科
放射学放射学是一门学科.

背景情况:

甲状腺相关眼病 (TAO) 影响视觉通路,但其对白质微观结构的影响还未得到充分研究.
与传统的DTI相比,先进的扩散MRI技术,如自由水 (FW) 和神经元导向分散和密度成像 (NODDI),为检测白质变化提供了更好的灵敏度.
有限的研究存在于应用多扩散成像来调查TAO相关的微观结构变化.

研究的目的:

用FW和NODDI研究TAO患者视觉通路中的白质微结构变化.
为了将观察到的微观结构变化与疾病严重程度和心理健康的临床测量相关联.

主要方法:

从45名TAO患者和31名健康对照 (HC) 获得多扩散MRI扫描.
基于路径的空间统计 (TBSS) 分析使用八个FW和NODDI衍生的指标进行.
研究了微观结构指标和临床分数 (HAMA,HAMD,GO-QOL2) 之间的相关性.

主要成果:

与HC相比,TAO患者的白质微观结构发生了显著的改变,包括较低的自由水校正小分异构 (fwFA) 和自由水校正轴向扩散率 (fwAD).
在TAO患者中观察到自由水校正平均扩散率 (fwMD),自由水校正辐射扩散率 (fwRD) 和方向分散指数 (ODI) 的增加 (p <0.05).
ODI显示了最高的诊断性能 (AUC),以及几个FW/NODDI指标与HAMA,HAMD和GO-QOL2得分有显著的相关性.

结论:

FW和NODDI指标有效地检测TAO患者的白质微结构异常.
这些微观结构变化与视觉通路有关,可能会影响患者的心理健康.

关键词:

dMRI (扩散磁共振成像) 是一种磁共振成像技术.免费的水扩散张力成像成像神经元的定向分散和密度成像.甲状腺相关的眼科病变基于路径的空间统计数据.

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