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在基于机器学习模型的自身免疫性尿道炎中探索与铁亡相关的基因TGFBR1的机制

Danlei Zhang¹, He Ren¹, Yiqiao Xing¹

¹Eye Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province 430060, People's Republic of China.

|July 14, 2025

概括

转化生长因子β受体1 (TGFBR1) 在自身免疫性脑膜炎 (AU) 发病过程中起着关键作用. 抑制TGFBR1可以缓解炎症和铁亡,这表明它是视力丧失的治疗点.

科学领域:

眼科医生眼科眼科
免疫学免疫学免疫学
细胞生物学细胞生物学

背景情况:

自身免疫性脑膜炎 (AU) 导致眼内炎症和视力丧失.
作为细胞死亡途径的铁亡,在AU的病原发生方面还没有得到充分的研究.

研究的目的:

在AU中调查与铁亡相关的基因.
确定关键基因及其在AU中的作用.
为AU机理学研究提供理论基础.

主要方法:

下载的基因表达综合 (GEO) 数据集 GSE198533.3.
进行了差异基因表达 (DEG) 分析和加权基因共表达网络分析 (WGCNA).
利用机器学习模型和实验性自身免疫性脑膜炎 (EAU) 的小鼠模型.

主要成果:

TGFBR1和ZFAS1被确定为关键的枢纽基因.
在EAU小鼠中,TGFBR1的表达下调.
TGFBR1过度表达加剧了炎症和铁;通过Galunisertib抑制缓解了症状.

结论:

在AU病原发生过程中,TGFBR1将铁和免疫失衡联系在一起.
TGFBR1可以作为AU的生物标志物和治疗点,特别是在BD相关的脑膜炎中.

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TGF - β Signaling Pathway

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