在外科手术期间穿皮尼古丁贴片对术后疼痛的影响:系统性审查和元分析
Bharat Yalla1, Puneet Khanna1, Soumya Sarkar2
1Department of Anaesthesiology, Pain Medicine, and Critical Care, AIIMS, New Delhi, India.
Indian journal of anaesthesia
|July 14, 2025
概括
在外科手术期间,通过皮肤的尼古丁贴片并没有显著减少术后疼痛. 虽然吸烟者可能会受益,但需要更多的研究来证实这种对疼痛管理的影响.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 尼古丁替代疗法 (NRT) 正在探索术后疼痛管理.
- 之前的研究缺乏对服用途径和吸烟者身份的区分.
- 通过皮肤注射尼古丁贴片治疗疼痛的有效性尚不清楚.
研究的目的:
- 为了确定外科手术期间穿皮尼古丁贴片对术后疼痛的影响.
- 为了比较吸烟者和接受尼古丁贴片的非吸烟者与安慰剂之间的结果.
- 进行随机对照试验的系统审查和元分析.
主要方法:
- 12项随机对照试验 (RCT) 的系统审查和元分析.
- 在多个数据库 (MEDLINE,EMBASE,CENTRAL等) 进行了搜索. 按照PRISMA的指导方针进行.
- 分析了疼痛评分,阿片类药物消耗,止痛时间,PONV和患者满意度.
主要成果:
- 在24小时内,尼古丁贴片和安慰剂组之间的疼痛评分 (NRS) 没有显著差异 (MD -0.24,P=0.13).
- 手术后阿片类药物消费没有显著差异 (MD -0.92,P=0.66).
- 没有观察到时间到第一次救援止痛,PONV或患者满意度的显著差异.
结论:
- 与安慰剂相比,外科手术期间的皮肤上尼古丁贴片并没有显著减少术后疼痛.
- 观察到吸烟者可能减少疼痛,但证据不足.
- 需要进一步的研究,特别是关于对不同患者群体的影响和结果的适当信息大小.
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