功能障碍是结肠直肠癌复发和预后的预测因素
Xuekang Ren1, Shaogong Zhu1, Rongzhen Li1
1Department of General Surgery, The Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China.
Frontiers in oncology
|July 14, 2025
概括
估计的淋巴膜过率 (eGFR) 预测结直肠癌 (CRC) 的复发和预后. 较低的eGFR表明较差的结果,突出显示功能.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床医学 临床医学
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 通过估计的淋巴膜过率 (eGFR) 评估的功能可能会影响CRC的结果.
- 了解这种关系可以改善患者管理.
研究的目的:
- 研究eGFR与结直肠癌患者的复发和预后之间的关联.
- 确定eGFR是否是CRC临床结果的独立预测因子.
主要方法:
- 在2018-2021年期间诊断出93名CRC患者的回顾性分析.
- 评估人口统计,疾病特征和功能 (eGFR).
- 用于分析关联的多变量考克斯回归,物流和波松模型;用于非线性关系的受限制立方支柱 (RCS).
主要成果:
- 慢性肺癌患者经常表现出脏过和尿液缩能力受损.
- 较低的eGFR (<90毫升/分钟和90-110毫升/分钟) 与较低的eGFR≥130毫升/分钟相比,与更差的预后显著相关.
- eGFR是一种独立的防治CRC复发的保护因子 (OR=0.964,P=0.032).
- 在eGFR和CRC复发之间观察到显著的非线性关系 (P<0.001).
结论:
- 结肠直肠癌患者经常出现功能障碍.
- eGFR是CRC患者疾病复发和整体预后的重要独立预测因子.
- 监测eGFR可能对管理CRC患者至关重要.
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