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在儿童肺结核中RISK6试验的诊断准确性
S Pouzol1, M K M Uddin2, A Islam2
1Medical and Expertise Division, Fondation Mérieux, Lyon, France.
IJTLD open
|July 14, 2025
概括
风险6试验对在幼儿中诊断结核病 (TB) 有希望,在识别需要进一步评估的儿童方面,其表现优于其他测试. 它为特定儿科群体的结核病例识别提供了一个具有成本效益的策略.
科学领域:
- 儿童传染病 儿童传染病
- 诊断测试开发开发的诊断测试
- 全球卫生健康 全球卫生健康
背景情况:
- 世界卫生组织 (WHO) 更新了其针对结核病 (TB) 在外围水平的识别的目标产品概况 (TPP),以指导新的测试开发.
- 准确和及时的儿童结核病诊断仍然是一个重大的全球卫生挑战.
研究的目的:
- 评估RISK6试验的诊断准确性和成本效益,以确定15岁以下儿童的肺结核 (TB).
- 为了比较RISK6试验的性能与现有的诊断方法,如曼托克斯试验和胸部X射线.
主要方法:
- 一项前性诊断准确性研究对365名怀疑患有肺结核的15岁以下门诊患者进行了研究.
- 该研究评估了RISK6试验的准确性,并在孟加拉国国际腹疾病研究中心 (icddr,b) 进行了每TB病例识别成本分析.
主要成果:
- 在365名儿童中,68人确诊结核病,94人未确诊结核病,203人不太可能患结核病.
- 风险6没有满足世卫组织对一般儿科结核病诊断的TPP,但在在12个月以下的婴儿中识别假定的肺结核病方面表现出色,表现优于曼托克斯和胸部X射线.
- 风险6,单独或与曼托克斯测试,证明成本有效的结核病识别和确认,特别是在12个月以上的儿童 (每病例132.00美元).
结论:
- 虽然没有满足世卫组织对所有儿科结核病病例的TPP要求,但RISK6试验显示出作为分拣工具的潜力.
- 风险6测定对12个月以下的儿童尤其有希望,可以作为世卫组织推的综合治疗算法中的决策支持工具.
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