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Updated: Sep 15, 2025

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通过PRC2介导的亡逃避是MDS/AML的治疗点,其中包括inv{3}/t{3}/t{3}和单体7的治疗点

Hiroyoshi Kunimoto1, Ayaka Miura1, Maiko Sagisaka2

  • 1Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama Japan.

HemaSphere
|July 14, 2025
PubMed
概括

骨髓发育综合征 (MDS) 和急性骨髓白血病 (AML) 具有inv3 / t3 / 3和单体7是攻击性的. EZH2 抑制剂通过向 EVI1-PRC2-GADD45γ 轴诱导亡,揭示了治疗的脆弱性.

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