在积极的社交方法中神经激活的减少与对社交焦虑障碍的避开训练更好的反应有关
Christopher Hunt1,2, Morgan M Caudle3, Martin P Paulus4
1VA San Diego Center of Excellence for Stress and Mental Health, USA.
Journal of mood and anxiety disorders
|July 14, 2025
概括
社会焦虑障碍 (SAD) 患者在接近积极的社会线索时,神经活动减少. 在特定的大脑区域的较低基线激活预测了对积极接近-积极接近-避免训练 (AP-AAT) 的更好的反应.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 精神病学是一个精神病学.
背景情况:
- 社会焦虑障碍 (SAD) 与积极的社会刺激的减少有关.
- 积极方法-避免方法培训 (AP-AAT) 旨在减少这种偏见,但结果不一.
- 对于在接近过程中具有潜在神经缺陷的个体来说,AP-AAT可能更有效.
研究的目的:
- 确定与SAD中减少的积极社会刺激方法相关的神经区域.
- 调查这些区域的基线神经活动是否预测了对AP-AAT的治疗反应.
主要方法:
- 一项临床试验的二次分析,涉及40名SAD参与者和22名健康对照 (HCs).
- 功能性磁共振成像 (fMRI) 在社交方法避免任务期间.
- 抑郁症参与者被随机分配到AP-AAT或假训练;通过积极影响和社会联系变化评估治疗反应.
主要成果:
- 与HC患者相比,当接近积极的社会线索时,SAD患者在左侧中央叶片,右上侧叶片 (SPL) 和左舌环 (LG) 中的激活率较低.
- 在社交方法期间,右SPL和左LG的较低基线激活预测了AP-AAT组相比假的积极影响的更大改善.
结论:
- 在基线积极社会方法期间神经激活的减少与更好的AP-AAT反应有关.
- AP-AAT可能对SAD患者具有治疗向的特定神经方法缺陷特别有益.
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