肺表面活性剂对肺液平衡的作用
Gary F Nieman1,2, Egidio Beretta3, Joaquin Araos2
1Department of Surgery, Upstate Medical University, Syracuse, New York, United States.
概括
肺表面活性剂通过减少气膜表面张力来维持肺液平衡. 表面活性剂功能的丧失会增加表面张力,促进液体积累,并可能导致肺.
科学领域:
- 肺部生理学 肺部生理学
- 呼吸系统药物 呼吸系统药物
背景情况:
- 肺表面活性剂在膜力学中的作用于1929年被确定.
- 表面活性剂替代疗法彻底改变了婴儿呼吸困扰综合征 (RDS) 治疗.
研究的目的:
- 审查肺表面活性剂在维持肺液平衡中的作用.
- 讨论如何改变表面活性剂的功能有助于肺.
主要方法:
- 对肺表面活性剂功能的现有文献的审查.
- 对与肺外血管水量 (PEWV) 相关联的膜表面张力 (γ) 研究的分析.
- 基于斯塔林方程的计算建模的讨论.
主要成果:
- 增加的膜表面张力 (γ) 与增加的肺外血管水量 (PEWV) 有正相关.
- 高表面张力通过增加围气空间的亚大气压来提高微血管过率.
- 升高的表面张力通过降低间歇性水静压引起肺,而不是增加毛细管的透性.
结论:
- 肺表面活性剂对于维持肺液平衡至关重要.
- 高膜表面张力显著影响流体动力学,甚至在正常的毛细血管透性下,可能导致肺.
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