动脉堵塞期间肢体吸血对人类动脉巴罗反射的影响
Takuto Hamaoka1, Urs A Leuenberger1, Cheryl Blaha1
1Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States.
肢体静脉张张会激活同情反应. 这项研究发现,手臂或腿部的静脉膨胀显著增加了交感巴罗反射灵敏度 (SBRS),有助于增加交感活动.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统调节自主神经系统调节
- 巴罗反射功能的功能
背景情况:
- 周围静脉张张会触发反射交感激活 (静脉张张反射).
- 以前的研究表明,前臂静脉张张会增加交感巴罗反射灵敏度 (SBRS).
- 静脉张张对下肢巴罗反射灵敏度 (BRS) 的影响仍未得到研究.
研究的目的:
- 调查一种假设,即上肢或下肢的静脉张张会改变巴罗反射灵敏度 (BRS).
- 为了确定下肢静脉张张是否会影响交感和心血管巴罗反射灵敏度.
主要方法:
- 20名健康的受试者接受了由负压 (100mmHg2分钟) 诱导的静脉张张在塞的手臂或腿部 (塞和吸入;O&S).
- 对照试验涉及肢体封闭,没有负压.
- 记录了每次的血压,心率和肌肉交感神经活动 (MSNA),并计算了SBRS和心血管BRS (CBRS).
主要成果:
- 无论是手臂O&S还是腿O&S都显著增加了血压和MSNA (P <0.05).
- 手臂O&S和腿O&S显著提高了SBRS,并导致SBRS曲线中点 (T50) (P <0.05) 向右转移.
- 无论是单独的肢体封闭还是任何干预都没有改变CBRS.
结论:
- 前臂和腿部的静脉张张会对巴罗反射灵敏度产生类似的影响.
- 观察到的SBRS的增加及其中点向右移动可能解释了静脉张张期间同情活动的增加.
- 这些发现为在造成肢体静脉张张的生理压力期间对自主调节机制提供了新的见解.
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