相关实验视频

Updated: Sep 15, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

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基因组突变H2A.Z与EBNA1合作,维持爱斯坦-巴尔病毒潜伏表观基因组

Leonardo Josué Castro-Muñoz1, Davide Maestri1, Leena Yoon1

  • 1The Wistar Institute, Philadelphia, Pennsylvania, USA.

mBio
|July 14, 2025
PubMed
概括

组织蛋白变体H2A.Z.1通过与EBNA1合作调节病毒染色质,帮助维持爱斯坦-巴尔病毒 (EBV) 延迟. 削减H2A.Z.1会重新激活病毒并破坏表观遗传编程.

关键词:
爱斯坦-巴尔病毒病毒.这是表观遗传学.疹病毒 疹病毒基因组 基因组 基因组延迟时间 延迟时间

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Histone Variants at the Centromere02:30

Histone Variants at the Centromere

Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Position-effect Variegation02:32

Position-effect Variegation

In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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Spreading of Chromatin Modifications

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Heterochromatin02:38

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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
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