在不同疫苗覆盖场景下,评估男性疫苗接种对中国宫癌消除的影响:一项建模研究
Ibrahim Diakite1, Jeffrey Kyle1, Sujian Situ2
1Health Economic and Decision Sciences, Merck & Co., Inc., Rahway, NJ, USA.
Human vaccines & immunotherapeutics
|July 14, 2025
概括
用9价值HPV疫苗 (9vHPV) 进行性别中立疫苗接种 (GNV) 和增加查加速了中国的宫癌消除. 将男性纳入疫苗接种和促进接种是公共卫生的关键策略.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 宫癌主要是由人类乳头瘤病毒 (HPV) 引起的,是中国的主要公共卫生问题.
- 目前在中国的HPV疫苗接种和宫癌查率低于世卫组织的目标.
研究的目的:
- 评估性别中立疫苗接种 (GNV) 策略对中国宫癌消除的影响.
- 在不同的疫苗接种覆盖率 (VCRs) 和查吸收场景下比较双价 (2vHPV) 和非价 (9vHPV) 疫苗的有效性.
主要方法:
- 一个数学模型被用来预测子宫癌的发病率和病例超过100年在中国.
- 模拟评估了不同的GNV策略,包括2vHPV和9vHPV疫苗,在不同的VCR和查吸收水平.
- 据估计,要达到世卫组织每10万女性4例消除门的时间.
主要成果:
- 与仅针对女孩的疫苗接种相比,GNV策略显示出优越的宫癌预防.
- 基于9vHPV的策略比2vHPV更有效,特别是在较低的女性录像机上.
- 最快的消除 (65岁) 是通过GNV-9vHPV在70%的查和60%的女性VCR实现的,加速到56岁在90%的女性VCR.
结论:
- 更新中国的HPV疫苗接种计划,包括男性,并利用9vHPV,提供了消除子宫癌的最有效途径.
- 增加查普及率和实施追赶疫苗接种计划可以进一步加速疾病的消除,特别是低VCRs.
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