与心周溢血的发展和系统性硬化症的持续性相关的因素:单中心回顾性分析
Nikolaos Koletsos1, Evripidis Kaltsonoudis1, Eleftherios Pelechas1
1Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Stavrou Niarchou Avenue, 45500, Ioannina, Greece.
Rheumatology international
|July 14, 2025
概括
心周溢出 (PerEff) 在全身性硬化症 (SSc) 中很常见. 这种心脏病与肺高血压,肺部疾病,脑膜异位症和炎症有关,影响了SSc患者的治疗.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
背景情况:
- 心脏参与是系统性硬化症 (SSc) 死亡的主要原因.
- 心周溢出 (PerEff) 是SSc患者的一种已知的心脏表现.
- 了解SSc中PerEff的患病率和相关因素对于患者管理至关重要.
研究的目的:
- 为了确定系统性硬化症患者中永久性和持续性心周输液的患病率.
- 确定与SSc.中心周溢液的存在和持续相关的临床和血清学因素.
主要方法:
- 对290名来自门诊病房的成人SSc患者进行了回顾性研究,直到2024年6月.
- 收集的数据包括人口统计,疾病特征,血清学和器官参与.
- 根据心声图的结果,患者被分为单一,持久或从未PerEff组.
主要成果:
- 24.5%的SSc患者至少有一次心电图对PerEff呈阳性; 13.2%的患者持久的PerEff.
- 曾经的PerEff与肺高血压 (PH),间歇性肺病 (ILD), telangiectasias 和升高的ESR有关.
- 持久的PerEff显示与PH,ILD,telangiectasias和升高的ESR有类似的关联.
结论:
- 心周溢出是系统性硬化症的常见表现.
- 存在PH,ILD,telangiectasias和升高的炎症标志物是SSc中PerEff的显著预测因素.
- 这些发现强调了监测SSc中的PerEff对于改善疾病过程和治疗策略的临床重要性.
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