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1型糖尿病中的心上脂肪组织:系统性审查和元分析
Basavaraj G Sooragonda1, Vanshika Karnwal2, Vikneswaran Gunaseelan1
1Narayana Health Bengaluru, Bengaluru, India.
概括
在1型糖尿病患者 (T1DM) 中,心表脂肪组织 (EAT) 增加. 这项研究量化了EAT厚度和体积,发现T1DM个体的测量比对照人群高,表明EAT.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 代谢研究研究 代谢研究
背景情况:
- 脊心脂肪组织 (EAT) 是围绕心脏的代谢活跃的脂肪库.
- EAT与心血管并发症有关,特别是1型糖尿病 (T1DM).
- 了解T1DM中的EAT对于评估心血管风险至关重要.
研究的目的:
- 在T1DM患者中系统地审查和量化EAT测量 (厚度和体积).
- 为了比较T1DM患者和健康对照组之间的EAT测量.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane,Web of Science,CINAHL) 进行了系统的文献搜索.
- 包括使用成像技术测量T1DM患者的EAT厚度或体积的研究.
- 用随机效应模型进行了元分析,通过纽卡斯尔-太华尺度评估质量.
主要成果:
- 包括9项研究,包括285名T1DM参与者.
- 聚合平均EAT厚度为5.81毫米,平均EAT体积为56.84厘米3.
- T1DM患者的平均EAT厚度比对照组大2.12毫米,观察到显著的异质性.
结论:
- 与健康个体相比,T1DM患者表现出显著增加的副心脏脂肪组织测量.
- 在T1DM中增加的EAT表明其在心血管并发症的发展中可能发挥作用.
- 需要进一步研究EAT对T1DM心血管健康的影响.
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