患有自闭症谱系障碍的中国男孩的语言能力的白质相关:一个扩散性皮质变异成像研究
Xuerui Lv1, Pu Tian1, Xiaona Zhu1
1Department of Radiology, the First Hospital of Jilin University, Changchun, Jilin, 130021, China.
European journal of pediatrics
|July 14, 2025
概括
患有自闭症谱系障碍 (ASD) 的男孩显示白质完整性降低,特别是在与语言有关的区域. 这些差异在严重语言困难的人中更为明显,突出了关键的神经生物学因素.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 儿童心理学 儿童心理学
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是语言能力多样化,语言延迟是一个敏感的指标.
- 之前的扩散张力成像 (DTI) 研究已经注意到ASD中的白质异常,特别是在语言处理区域.
研究的目的:
- 用扩散性皮质成像 (DKI) 来研究ASD男孩的白质微结构差异.
- 探索这些白质变异与ASD语言能力之间的关系.
- 为了比较ASD小组与轻度和重度语言困难之间的白质完整性.
主要方法:
- 在61名自闭症男孩和30名典型发育 (TD) 同龄人身上利用了DKI和基于通道的空间统计 (TBSS).
- 使用格里菲斯发展尺度-中文版 (GDS-C) 评估语言能力,使用自闭症行为检查清单 (ABC) 评估行为症状.
- 与临床规模得分相关的扩散指标,以检查与语言困难的关系.
主要成果:
- 与TD同龄人相比,患有ASD的儿童在关键通道 (例如,体,上纵) 中白质完整性降低.
- 在具有显著语言困难的ASD亚组中,这些减少更为严重.
- 白质区的特定皮质量指标显示,在轻度和重度语言困难子组中,与语言子级分数有显著的关联.
结论:
- 在特定区域减少白质微结构完整性是ASD男孩语言困难的潜在神经生物学因素.
- 患有自闭症和严重语言障碍的男孩表现出更明显和更广泛的白质变化.
- DKI揭示了与ASD语言严重程度相关的分级白质变化,为神经生物学基础提供了新的见解.
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