团队交付的基于正念的认知疗法,以减少心理痛苦和改善炎症性肠道疾病患者的睡眠:多中心随机对照试验 (MindIBD)
Milou M Ter Avest1,2,3, Marloes J Huijbers1, Carmen S Horjus4
1Department of Psychiatry, Centre for Mindfulness, Radboud University Medical Centre, Nijmegen, the Netherlands.
基于正念的认知疗法 (MBCT) 显著减少了炎症性肠病 (IBD) 患者的心理痛苦,改善了他们的幸福感. 在12个月的时间里,MBCT也对睡眠和炎症标志物产生了积极的影响.
科学领域:
- 胃肠病学 胃肠病学
- 心理学 心理学 心理学
- 睡眠医学 睡眠医学
背景情况:
- 炎症性肠病 (IBD) 患者经常经历心理困扰和生活质量降低,即使在缓解期间.
- 基于正念的认知疗法 (MBCT) 是一种潜在的干预措施,用于改善各种患者群体的心理健康.
- 在IBD患者中,MBCT的疗效需要进一步研究.
研究的目的:
- 评估MBCT与常规治疗 (TAU) 相结合的有效性与TAU单独的有效性,以减少IBD患者的心理痛苦.
- 评估MBCT对患者福祉和睡眠质量的影响.
主要方法:
- 一个多中心随机对照试验 (NCT04646785),涉及142名IBD患者 (年龄≥16岁),患有轻度至重度心理困扰.
- 参与者接受了MBCT加TAU或单独TAU,在基线,3,6,9和12个月后进行评估.
- 用医院焦虑和抑郁量表来测量心理困扰,并与客观睡眠指标和便calprotectin水平一起进行测量.
主要成果:
- 与单独TAU相比,MBCT加TAU显著降低了心理痛苦 (d=-0.61) 和改善了幸福感 (d=0.40),具有持续的影响.
- 探索性睡眠分析表明,在MBCT后,总睡眠时间减少 (d=0.67),深度睡眠增加 (d=0.70).
- 没有观察到发作发生的差异,但在MBCT加TAU组 (d=-0.49) 中,便calprotectin水平下降.
结论:
- 对于IBD患者来说,MBCT是一种有价值的心理社会干预,有效地减少了心理痛苦并提高了幸福感.
- 这些发现表明,MBCT可能会积极影响生物过程,包括睡眠模式和炎症.
- MBCT提供了一个有前途的辅助疗法,用于管理IBD患者面临的多方面的挑战.
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