在不同的物种中,肥胖诱导了骨肌肉的转录性变化
Yujie Wang1,2, Jiaman Zhang1, Xintong Yang1
1Livestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
PloS one
|July 14, 2025
概括
猪抵抗肥胖引起的骨肌肉炎症,与人类和小鼠不同. 它们的基因家族以不同的方式进化,为代谢障碍和潜在的治疗点提供了洞察力.
科学领域:
- 进行比较的基因组学.
- 代谢性疾病研究研究.
- 骨肌肉生理学 骨肌肉生理学
背景情况:
- 肥胖会导致人类和小鼠骨肌肉的代谢失调和炎症.
- 猪骨肌肉对肥胖的反应不太清楚.
- 猪在高脂肪饮食中保持新陈代谢平衡,并抵抗肝脏肥胖症,与人类和小鼠不同.
研究的目的:
- 描述肥胖猪骨肌肉转录变化的特征.
- 为了将猪骨肌肉转录组与肥胖的人类和小鼠进行比较.
- 研究基因家族的进化和表观遗传调节,以应对跨物种的肥胖.
主要方法:
- 构建了肥胖猪的骨肌肉转录组.
- 综合数据与肥胖人类和小鼠的公共转录资料.
- 分析了来自不同物种的瘦个体的ATAC-seq数据.
- 专注于基因家族,正义基因和表观遗传调节.
主要成果:
- 肥胖会激活脂质代谢,并抑制猪骨肌肉中的免疫反应基因,与人类和小鼠形成鲜明对比.
- 猪中的扩大基因家族 (嗅觉受体,α-氨酶,ABC载体) 在肥胖中被上调.
- 在不同物种中发现了参与脂质代谢,炎症和免疫细胞激活的不同变化的基因.
- 高分歧基因表现出保存的序列和更大的促进器染色质可访问性.
结论:
- 特定物种的基因家族进化和转录可塑性有助于肥胖反应的分歧.
- 快速演变的基因家族和不同表达的基因为与肥胖相关的代谢障碍提供了洞察力.
- 识别潜在的转录因子结合部位可能会揭示代谢疾病的新治疗点.
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