非酒精性脂肪性肝病的周期并发症诊断:基于美国人口的回顾性分析
Richie Manikat1, Sally Tran1, Leslie Yeeman Kam1
1Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California, USA.
Digestive diseases (Basel, Switzerland)
|July 14, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 的诊断往往会延迟,三分之二的患者在肝脏并发症后被诊断出来. 胃肠病或代谢疾病专家的早期干预显著降低了并发症的风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 代谢疾病 代谢疾病
背景情况:
- 对与代谢功能障碍相关的脂肪性肝病 (MASLD) 的查指南,以前是非酒精性脂肪性肝病,正在讨论中.
- 早期诊断MASLD对于及时干预和预防策略至关重要.
研究的目的:
- 调查MASLD诊断的时间与肝脏并发症有关.
- 为了确定与延迟MASLD诊断相关的因素.
主要方法:
- 使用MerativeTM Marketscan®数据库 (2007-2021) 对被诊断患有MASLD和肝脏并发症的成年患者的回顾性分析.
- 纳入标准要求在第一次肝脏并发症之前至少有12个月的保险覆盖.
- 多变量逻辑回归被用来分析与延迟诊断相关的因素.
主要成果:
- 分析了超过143,000名患者,66.8%的患者接受了MASLD诊断.
- 患有危险复杂性诊断的患者年龄较大,更有可能有烟草/非法药物使用史,代谢性疾病和更高的并发症得分.
- 与胃肠病学或代谢专家 (心脏病学,内分泌学,科) 的早期咨询与延迟MASLD诊断的几率明显降低有关.
结论:
- 在现实环境中,MASLD诊断显著延迟,大多数患者在肝脏并发症开始时或之后被诊断出来.
- 胃肠病学和代谢专家对患者进行长途随访,与MASLD患者早期肝脏并发症风险降低有关.
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