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在腹膜透析开始时单细胞与淋巴细胞的比率升高预测了长期腹膜炎风险:一项回顾性队列研究

Lin Zhang^1,2,3,4, Li Wang^5,6,7,8, Xiaotian Jiang^5,6,7,8

¹Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China, zhanglin_melody@126.com.

Blood purification

|July 14, 2025

概括

在腹膜透析 (PD) 开始时,单细胞与淋巴细胞比率 (MLR) 较高,预测腹膜炎风险增加. 这种简单的炎症标志物可以帮助分层患者进行早期干预,特别是更瘦的个体.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
炎症标志物是一种炎症标志物.
发现生物标志物的发现.

背景情况:

腹膜透析 (PD) 相关的腹膜炎是一种影响患者发病率和治疗成功的重大并发症.
识别腹膜炎的预测生物标志物对于PD患者的及时干预至关重要.
单细胞与淋巴细胞比率 (MLR) 是一个新兴的炎症标志物,但其在PD周周炎风险中的作用尚未得到充分证实.

研究的目的:

调查单细胞与淋巴细胞比率 (MLR) 之间的关联,以及在接受腹膜透析 (PD) 的患者中患腹膜炎的风险.
评估MLR作为PD患者周周炎的潜在预测生物标志物.

主要方法:

对108名PD患者进行了回顾性队列研究,追踪时间为36个月.
单细胞与淋巴细胞的比率 (MLR) 测量在PD导管插入时.
考克斯的比例危险模型和受限立方线回归 (RCS) 分析了MLR与腹膜炎风险的关联,并对共变量进行调整.

主要成果:

在随访期间,30.6%的患者患有腹膜炎.
较高的MLR独立地与炎风险增加有关 (aHR=1.85,p=0.048).
最高的MLR三位数显示风险增加了六倍 (p为趋势=0.002),并确定了非线性关联.

结论:

在PD开始时MLR升高是长期腹膜炎风险的独立预测指标.
MLR可以作为一种简单的,具有成本效益的生物标志物,用于早期腹膜炎风险分层.
在较瘦的PD患者 (BMI <24 kg/m2) 中,这种关联似乎更强烈.

关键词:

炎症生物标志物炎症生物标志物单细胞与淋巴细胞的比率.腹膜透析是指腹膜透析.腹膜透析相关的腹膜炎

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