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诊断神经认知障碍的临床途径:从一个记忆诊所队列的过程挖掘的见解

Claudio Singh Solorzano¹, Stefania Orini², Cristina Festari¹

¹Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Journal of the American Medical Directors Association

|July 14, 2025

概括

过程挖掘可视化痴呆症诊断旅程,显示诊断通常在第三次访问时使用仪器检查和生物标志物达到. 这种方法为记忆诊所的患者护理途径提供了现实的视图.

科学领域:

医疗信息学医疗信息学
神经科学是一个神经科学.
医疗保健管理的管理

背景情况:

过程挖掘 (PM) 是一种新的技术,最近被引入医学领域.
由于其广泛的影响和经济负担,痴呆症诊断带来了挑战.
了解患者的诊断途径对于改善记忆诊所护理至关重要.

研究的目的:

在记忆诊所环境中应用过程挖掘 (PM).
为了可视化和分析患者痴呆的诊断途径.
为痴呆患者的诊断旅程提供现实的概述.

主要方法:

对539张医疗病历进行了回顾性观察性研究.
利用过程挖掘 (PM) 来绘制临床事件和患者旅程.
分析了诊断评估的时间序列,包括成像和生物标志物.

主要成果:

诊断通常发生在第三次临床访问时,在仪器检查和初始生物标志物之后.
在MCI和DEM亚队中,脑脊液分析是疑似阿尔茨海默病的常见一线生物标志物 (23%) .
与轻度认知障碍 (MCI) 患者相比,患有痴呆症 (DEM) 的患者在进入诊所之前更有可能进行成像.

结论:

过程挖掘 (PM) 有效地可视化和量化真实世界的诊断途径在记忆诊所.
这种方法为患者的痴呆症护理之旅提供了宝贵的见解.
初步结果表明,PM是优化诊断过程的有希望的工具.

关键词:

痴呆症是一种痴呆症.临床途径临床途径诊断诊断诊断诊断诊断诊断过程采矿过程采矿

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