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Updated: Sep 15, 2025

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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Published on: June 26, 2020

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PAXX/Ku 相互作用是修复需要最终处理的双链DNA断裂的速度限制

Joanna Gluza1, Joanna Machnik2, Malgorzata Szatkiewicz1

  • 1Łukasiewicz Research Network - Polish Center for Technology Development, Wrocław, Poland.

The Journal of biological chemistry
|July 14, 2025
PubMed
概括

PAXX蛋白中的突变稳定了DNA修复复合体,加速了双链断裂 (DSB) 的非同类末端连接 (NHEJ). 这表明修复复合体的稳定性是哺乳动物NHEJ的速度限制步骤.

关键词:
造成的DNA损伤是DNA损伤.对DNA损伤的反应反应修复DNA的修复DNA的修复在DSB中,DSB是DSB.这就是NHEJJ.PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX PAXXXX双链断裂是双链断裂的一个原因.分子生物学分子生物学不同类型的末端连接.核的核心是核的核.

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