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Updated: Sep 15, 2025

Utilization of Grafix for the Detection of Transient Interactors of Saccharomyces cerevisiae Spliceosome Subcomplexes
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Published on: November 9, 2020

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对于准14-3-3/ERα复合体的分子合剂的架构跳跃.

Markella Konstantinidou1, Marios Zingiridis2, Marloes A M Pennings3

  • 1Department of Pharmaceutical Chemistry and Small Molecule Discovery Centre (SMDC) University of California San Francisco (UCSF), San Francisco, CA, USA. markella.konstantinidou@ucsf.edu.

Nature communications
|July 14, 2025
PubMed
概括

研究人员使用脚手架跳跃和多组件反应化学开发了新的分子,以准蛋白质-蛋白质相互作用 (PPI). 这种方法可以快速优化挑战"不可抗药"目标,如14-3-3/雌激素受体α复合体.

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