与MOGAD相关的:年龄相关的临床,流体,成像和神经生理特征的系统性表征
Martina Rubin1,2,3,4, Gianni Cutillo2,3,4,5, Vittorio Viti2,3,4
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Journal of neurology
|July 14, 2025
概括
是髓寡基核糖蛋白抗体相关疾病 (MOGAD) 的显著表现,特别是在儿科患者中,与成人相比,他们面临更高的慢性风险.
科学领域:
- 神经免疫学 神经免疫学
- 中枢神经系统疾病 中枢神经系统疾病
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 髓寡干细胞糖蛋白抗体相关疾病 (MOGAD) 是一种罕见的,异质的中枢神经系统 (CNS) 脱髓化疾病.
- 是所有年龄组中常见但不太了解的MOGAD表现.
研究的目的:
- 在MOGAD中划分的特定年龄的临床,流体,成像和神经生理学特征.
- 为了比较儿科发作和成人发作MOGAD患者之间的特征.
主要方法:
- 在2025年4月之前对在线存储库进行系统审查,包括178项符合条件的研究.
- 来自临床研究的2487名MOGAD患者和337名病例报告/病例系列的分析.
- 患者的分层分为儿科发病 (n=197) 和成人发病 (n=140) 组.
主要成果:
- 发作发病率在儿科发病 (30.6%) 和成人发病 (7%) 中较高.
- 儿科发病的MOGAD患者更容易发生状态,脑病变和慢性.
- 成人开始的MOGAD显示出较高的脑脊液细胞形成和明显的损伤模式 (叶卷入).
- 与其他抗体,特别是抗NMDAR的共同阳性发生在37.3%的患者中,没有特定年龄的差异.
结论:
- 是一种重要的MOGAD相关疾病,具有显著的慢性风险.
- 在MOGAD的呈现和结果存在年龄特定的差异.
- 需要进一步的前性研究来指导针对MOGAD相关的适合年龄的治疗策略.
更多相关视频
10:22Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
Published on: December 6, 2016
20.5K
09:57Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
2.8K
相关概念视频
01:13Seizures: Classification
600
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
600
01:24Epilepsy and Seizures: Overview
285
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
285