在患有MAFLD的患者中,血清VIT D水平和胰岛素抵抗之间的关系
Alshymaa A Hassnine1, Amr M Elsayed2, Samar K Abdelaziez2
1Department of Tropical Medicine, Faculty of Medicine, Minia University, Minia, Egypt. Alshiamaa.Ahmed@mu.edu.eg.
BMC endocrine disorders
|July 14, 2025
概括
与代谢相关的脂肪肝疾病 (MAFLD) 患者的维生素D水平显著降低. 较低的维生素D与增加的MAFLD严重程度相关,这表明补充可能是有益的.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 代谢相关脂肪性肝病 (MAFLD) 是全球普遍存在的代谢性肝病,与代谢综合征和糖尿病密切相关.
- HOMA-IR是MAFLD进展到晚期纤维化和肝硬化的一个关键指标.
- 由于其与代谢功能障碍的强烈关联,NAFLD已被更名为MAFLD.
研究的目的:
- 研究被诊断患有MAFLD的患者血清维生素D水平和胰岛素抵抗之间的关系.
主要方法:
- 一项涉及120名参与者的横截面观察研究 (60名MAFLD患者,60名对照).
- 评估包括人体测量测量,全面的实验室测试 (包括血清维生素D和HOMA-IR),超声波和剪切波弹性图像.
主要成果:
- 与对照组 (15%) 相比,MAFLD患者的血清维生素D水平显著降低 (55%).
- 血清维生素D水平与肝硬化和纤维化程度的增加有显著的反相关性 (P < 0.001).
- 在MAFLD患者的血清维生素D和胰岛素抵抗之间观察到一个反向的,虽然不是统计学上显著的相关性.
结论:
- 患有MAFLD的人与没有这种疾病的人相比,血清维生素D水平较低.
- 维生素D水平的降低与脂肪肝疾病的晚期相关.
- 补充维生素D可能是管理MAFLD的潜在治疗策略.
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