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在未选定人群中PCOS表现型 (P-PUP) 研究:参与者的临床特征和对分析个体参与者数据的数据协调

Asmamaw Demis Bizuneh¹, Sylvia Kiconco¹, Arul Earnest²

¹Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, 3168, Australia.

|July 14, 2025

概括

这项研究协调了来自不同人群的数据,以提高对多囊性卵巢综合征 (PCOS) 诊断的理解. 这些发现突出了数据收集方面的挑战,但为未来的PCOS研究奠定了基础.

科学领域:

生殖内分泌学生殖内分泌学
流行病学流行病学
遗传学遗传学是一个

背景情况:

多囊性卵巢综合征 (PCOS) 带来了诊断挑战和临床异质性.
准确的诊断标准和切断值对于PCOS研究至关重要.
国际PCOS表现型在未选定人群 (P-PUP) 研究的目的是描述临床特征并协调数据.

研究的目的:

描述P-PUP研究中参与者的临床特征.
为国际PCOS研究协调个人参与者数据 (IPD).
为了解决PCOS的诊断挑战和临床异质性.

主要方法:

在EMBASE和Medline搜索了基于人口的,医学上公正的队列 (1990-2020).
包括300名以上参与者的研究,直接PCOS特征评估和IPD.
通过交叉引用,异常值识别和按照PRISMA-IPD指南的变量协调来确保数据完整性.

主要成果:

包括来自8个国家的12项研究中的9979名女性,代表11个种族.
在记录排卵功能障碍,临床高雄性和多囊性卵巢形态方面注意到了变化.
协调遵循国际指导方针;经调整后,PCOS总体患病率为11.0%.

结论:

P-PUP研究为PCOS研究提供了一个有价值的,多样化的,基于人口的队列.
数据收集和定义的变化给数据集成带来了挑战.
优化协调提供了洞察力,并为未来的PCOS合作研究奠定了基础.

关键词:

青青青的意思雄激素是一种基.数据统一和数据协调.女性模式脱发脱发方式希尔苏特主义 (Hirsutism) 是一个宗教信仰.在IPD中,IPD是IPD.个人参与者数据个人参与者数据在PCOS中,PCOS是PCOS.现象型现象型是一种现象型.多囊性卵巢是多囊性卵巢.多囊性卵巢综合征多囊性卵巢综合征

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