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Updated: Sep 15, 2025

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells

Published on: September 23, 2022

在MSC治疗中,外体介导机制的兴起

Weihua Liu¹, Sheng Chen², Yuan Wang²

¹Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Nanjing, China.

Journal of translational medicine

|July 14, 2025

概括

这项研究分析了对移植与宿主疾病 (GVHD) 中介质层细胞 (MSC) 的全球研究. 它绘制了出版趋势和合作,突出了MSC-GVHD疗法的新兴研究热点.

科学领域:

免疫学和移植科学免疫学和移植科学
生物医学研究生物医学研究
圣经计量学和科学计量学

背景情况:

移植与宿主疾病 (GVHD) 是全原造血细胞移植的一个主要并发症.
介酶体 stromal 细胞 (MSCs) 显示出缓解 GVHD 的承诺,因为它们具有免疫调节性质.
目前还没有对GVHD研究中的MSC进行全面的文献分析.

研究的目的:

进行对MSC为GVHD.基于治疗的全球研究的文献分析.
利用图库计量工具绘制出版趋势,协作网络和新兴研究热点.
确定MSC-GVHD研究领域的关键贡献者和不断发展的主题.

主要方法:

从2010年到2023年的出版物从科学网上获取.
用Citespace,VOSViewer和R包"bibliometrix"进行了图书识别分析.
共同作者,共同引用和关键词网络被构建和可视化以分析趋势和合作.

主要成果:

分析了来自58个国家的875篇出版物,显示了十年来研究的显著增长.
在MSC治疗中,细胞外囊泡和外体介导机制被确定为一个值得注意的重点.
确定了关键的合作网络 (例如,美中) 和新兴的研究热点.

结论:

本文献计量研究提供了MSC在GVHD的研究的全面概述.
研究结果揭示了全球趋势和合作模式,这对未来的研究和临床转化至关重要.
这些见解对于优化基于MSC的GVHD治疗策略至关重要.

关键词:

图书统计学分析城市空间 (Citespace) 是一个城市空间.移植对宿主疾病 (GVHD) 是一种移植对宿主疾病.介质细胞层细胞是介质细胞层细胞.翻译医学是一种翻译医学.在VOSViewer中使用VOSViewer.

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