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儿童发作的老年患者在7年内认知能力下降:基于人口的前性随访研究
Mira Karrasch1, Bruce Hermann2, Tove Roos1
1Department of Psychology, Åbo Akademi University, Turku, Finland.
概括
患有童年发作的的人表现出加速的认知衰退,特别是那些患有活跃的人. 即使在缓解期,情节性记忆功能也会下降,这表明大脑老化速度更快.
科学领域:
- 神经学 神经学
- 神经心理学 神经心理学
- 衰老研究研究 衰老研究
背景情况:
- 患有童年发作的的老年人的认知变化尚未得到充分理解.
- 长期前性研究对于跟踪认知轨迹至关重要.
研究的目的:
- 为了检查患有的老年个体在7年时间内的认知变化.
- 为了比较患有活跃,缓解和对照患者之间的认知轨迹.
主要方法:
- 一项基于人口的前性队列研究从20世纪60年代初开始跟踪参与者.
- 神经心理测试评估了语言,记忆,执行功能和视觉运动技能.
- 基于回归的标准化变化得分控制了测试-重新测试效应.
主要成果:
- 患有活动性的参与者表现出情节性记忆的显著下降.
- 经过缓解的患者在学习,立即回忆和设置转移方面出现下降.
- 活动性显著增加了一般认知能力下降的风险 (OR 61.25).
结论:
- 与对照组相比,儿童发作的与较差的认知轨迹有关.
- 活跃性带来了认知能力下降的高风险.
- 缓解性的风险较低,但仍会影响情节性记忆,表明大脑衰老加速.
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