粉样蛋白和心力衰竭相关死亡率的时间和地理差异:1999-2020年流行病学研究
Hoang Nhat Pham1, Ramzi Ibrahim2, Thi Nguyen1
1Department of Medicine, University of Arizona Tucson, Tucson, Arizona.
Current cardiology reviews
|July 15, 2025
概括
1999-2020年间,心力衰竭 (HF) 和粉样性粉症的死亡率显著增加,2013年以后急剧上升. 这一趋势凸显了针对性公共卫生干预的迫切需要,以解决护理差异.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 医疗信息学 医疗信息学
背景情况:
- 氨基粉症是一种严重的疾病,可以导致心力衰竭 (HF),显著增加死亡风险.
- 识别粉样粉症和HF患者的死亡率趋势对于了解该疾病随时间推移的影响至关重要.
研究的目的:
- 在22年的时间里 (1999-2020年) 分析与并发性粉样和心力衰竭相关的死亡率趋势.
- 为了确定阿米洛伊多सिस和HF患者死亡率的人口差异.
主要方法:
- 利用CDC死亡证书数据从1999年到2020年查询死亡原因.
- 计算了年龄调整后的死亡率 (AAMR) 并使用蒙特卡洛顺序测试来确定年度百分比变化 (APC).
- 采用日志线性回归来评估死亡率的时间变化,并确定拐点.
主要成果:
- 粉症和HF的年龄调整后死亡率从1999年的0.09增加到2020年的0.27.
- 从2013年到2020年,死亡率出现了显著的加快 (APC +13.3),随后从1999年到2013年 (APC +1.4) 的增长速度较慢.
- 在男性和黑人人口中,死亡率更高,2013年在所有分析的人口群体中观察到显著的拐点.
结论:
- 自2013年以来,粉样性粉症患者的HF相关死亡率显著增加,这表明诊断和治疗得到了改进.
- 在性别,种族和种族之间存在严重的死亡率差异,需要有针对性的公共卫生干预措施.
- 该研究强调,迫切需要解决这些差异,以缓解不断上升的死亡率.
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