一个脊髓切除术患者的Lactobacillus paracasei诱导的肺:一个罕见的病例报告
1Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Medicine
|July 15, 2025
概括
益生菌Lactobacillus paracasei可以在免疫功能低下的患者中引起肺,特别是在脊髓切除术后. 通过下一代测序和向抗生素的早期诊断对恢复至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 乳杆菌 (Lactobacillus paracasei,LP) 通常是一种益生菌,很少引起感染.
- 免疫功能低下的个体,特别是那些经过脊髓切除术的人,患机会性感染的风险更高.
- 本病例报告详细介绍了一种罕见的LP病例,导致严重的肺部感染.
研究的目的:
- 报告一个由 Lactobacillus paracasei 引起的肺的病例,该病例发生在脊髓切除患者身上.
- 突出下一代测序 (NGS) 在识别罕见病原体方面的诊断实用性.
- 强调量身定制的抗生素治疗在治疗机会性感染中的重要性.
主要方法:
- 一名65岁的脊髓切除术的男性出现了感染症状.
- 诊断工作包括成像 (揭示肺部,淋巴腺病,上腺节) 和肺孔活检.
- 使用下一代测序 (NGS) 来识别病原体,证实了Lactobacillus paracasei.
- 治疗涉及多学科合作和针对性抗生素治疗法罗.
主要成果:
- 下一代测序证实了Lactobacillus paracasei作为肺部的致病原体.
- 患者接受了针对性抗生素治疗,使用法罗胺.
- 观察到临床改善,症状消失,成功出院.
结论:
- 乳酸菌可作为一种机会性病原体,导致严重的肺在免疫功能低下,切除术患者.
- 使用NGS进行早期和准确的诊断对于有效的管理至关重要.
- 在这种情况下,多学科合作和病原体特异性抗生素治疗对于成功的结果至关重要.
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