非编码RNA对精神分裂症和精神分裂情绪障碍症状类型和认知功能的新兴作用
Kadriye Cansu Suguler1, Osman Zulkif Topak1, Osman Ozdel1
1Department of Psychiatry, University of Pamukkale, Denizli, Turkey.
概括
这项研究在精神分裂症患者中发现了较高的TMEVPG1表达,以及精神分裂情绪障碍中NRON表达,症状和认知功能之间的联系. 精神分裂症和精神分裂情绪障碍之间存在炎症标记的差异.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 精神分裂症和精神分裂情绪障碍涉及复杂的免疫失调.
- 像NRON和TMEVPG1这样的长非编码RNA (lncRNAs) 与免疫功能和神经系统疾病有关.
- 了解特定的分子标记可以区分这些情况,并告知治疗.
研究的目的:
- 为了比较IL-6 mRNA,NRON和TMEVPG1表达在精神分裂症和精神分裂情绪障碍患者与对照者的表达.
- 研究这些分子标记物与症状类型,认知功能和抗精神病治疗之间的关系.
主要方法:
- 实时PCR用于量化84名参与者 (精神分裂症,精神分裂情绪障碍,健康对照) 的lncRNA (TMEVPG1,NRON) 和IL-6mRNA表达.
- 认知功能和症状严重程度使用标准化神经心理测试和临床评级尺度进行评估.
主要成果:
- 与健康对照人群相比,精神分裂症和精神分裂情绪障碍患者的TMEVPG1表达增加.
- TMEVPG1表达式将精神分裂症病例与对照病例区分开来.
- 在精神分裂症中,NRON表达与积极症状正相关,并导致认知功能障碍.
- 在精神分裂症患者中,随着抗精神病剂量增加,NRON表达减少.
结论:
- 精神分裂症和精神分裂情绪障碍之间存在着炎症标志物表达及其与症状学和认知功能相关的显著差异.
- 这些发现突出了每个疾病的独特分子形状和潜在的治疗点.
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