根据2022年日本透析注册表的数据,冠状病毒疾病2019年疫苗增强剂的有效性
Yuka Sugawara1, Masao Iwagami2, Yuki Sakurai1
1Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan.
Nephrology (Carlton, Vic.)
|July 15, 2025
概括
接受COVID-19疫苗增压剂的日本血液透析患者显示感染风险和死亡率降低. 虽然第三剂对感染的有效性有所不同,但随后的增强剂在奥米克朗时代始终降低了风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- 欧米克朗变种显著影响了2019年冠状病毒病 (COVID-19) 疫苗的有效性,特别是在日本血液透析患者等弱势群体中.
- 了解多次COVID-19疫苗增剂剂量的影响对于管理免疫受损个体感染至关重要.
研究的目的:
- 为了评估日本血液透析患者的第三,第四和第五次COVID-19疫苗增剂剂量的有效性.
- 评估这些助推剂在Omicron变种主导期间对感染风险和死亡率的影响.
主要方法:
- 分析了日本透析治疗协会脏数据注册 (JRDR) 年终调查数据,从2021年到2022年.
- 按疫苗接种状态计算每月COVID-19感染和死亡风险.
- 后勤回归分析以确定感染和死亡率的调整几率比率 (aOR).
主要成果:
- 分析了超过225,000名血液透析患者,54.3%的人在2022年底前接受了五剂.
- 第三剂疫苗在2022年初显示感染风险降低,但在BA.1/2到BA.5过渡期间风险增加.
- 第三剂持续降低了COVID-19相关的死亡率,而第四剂和第五剂在整个研究期间降低了感染风险和死亡率.
结论:
- 第三到第五次COVID-19疫苗增剂剂量与日本血液透析患者的死亡率降低有关.
- 增剂剂量通常会降低感染风险,但在特定的Omicron亚变体转变期间的第三剂量有一些例外.
- 建议血液透析患者继续接种疫苗,以减轻COVID-19的风险.
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