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Updated: Sep 15, 2025

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Induction and Analysis of Epithelial to Mesenchymal Transition
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口腔微生物在表皮-半机细胞转换中的作用,以及癌症进展中的作用
Divya Gopinath1,2, Zhengrui Li3,4,5,6,7,8,9,10, Marwan Mansoor Mohammed11,12
1Basic Medical and Dental Sciences Department, College of Dentistry, Ajman University, Ajman, UAE.
Molecular oral microbiology
|July 15, 2025
概括
口腔微生物通过触发上皮层-介质细胞转换 (EMT) 来驱动癌症的进展. 了解这些机制可能会导致针对口腔微生物群和EMT的新型癌症疗法.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 表皮-介质细胞过渡 (EMT) 是一种细胞过程,对发育和疾病至关重要,其特征是表皮特征的丧失和介质细胞特征的增加.
- EMT增强细胞的运动性,侵入性和干性,促进瘤的进展和癌症转移.
- 新出现的证据将口腔微生物群与致癌症联系起来,在诱导EMT方面可能发挥作用.
研究的目的:
- 审查口腔微生物调节上皮层-介质细胞过渡 (EMT) 的机制.
- 阐明口腔微生物群诱导的EMT对癌症发展和转移的贡献.
- 突出开发基于这些机制的向治疗的潜力.
主要方法:
- 关于研究口腔微生物与癌症中的EMT之间的相互作用的文献综述.
- 对微生物对上皮细胞生物学影响的直接和间接机制的分析.
- 对微生物代谢物及其在EMT诱导中的作用的当前知识的综合.
主要成果:
- 口腔微生物可以通过破坏细胞间粘附和改变细胞极性来直接诱导EMT.
- 微生物代谢产物和化合物间接调节EMT通路,促进促进瘤原生环境.
- 口腔微生物群驱动的EMT对癌症的攻击性和转移有显著的贡献.
结论:
- 口腔微生物通过诱导EMT在促进癌症进展方面发挥着关键作用.
- 了解口腔微生物群和宿主细胞之间的分子交互是预防和治疗癌症的关键.
- 针对口腔微生物群和EMT途径为新型癌症治疗提供了有希望的途径.
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