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[不同尺寸的生物材料用于固体瘤中增强的采用细胞转移疗法]

Jiaxin Chen¹, Rui Liu², Yingqi Tang²

¹Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, State Key Laboratory of Natural Medicines, Nanjing 210009, China. 328465357@qq.com.

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

|July 15, 2025

概括

生物材料通过改善细胞传递,免疫反应和减少毒性来增强固体瘤的采用细胞转移 (ACT). 这种方法对推进癌症治疗有前途.

科学领域:

生物医学工程生物医学工程
癌症免疫疗法免疫疗法
材料科学材料科学材料科学

背景情况:

采用细胞转移 (ACT) 对血液癌症有效,但在固体瘤中面临挑战,包括细胞归宿不良,免疫抑制和毒性.
现有的局限性阻碍了ACT在固体瘤治疗中的广泛临床应用.

研究的目的:

审查基于生物材料的增强ACT在固体瘤中的疗效策略的最新进展.
突出生物材料如何克服ACT中的关键障碍,例如改善分娩,调节瘤微环境,减少副作用.

主要方法:

关于生物材料在ACT中的应用的科学文献的综述,涵盖纳米粒子,微球/微贴片和水凝.
分析不同生物材料类型如何促进瘤微环境的ex vivo细胞工程,in vivo输送和in situ调节.

主要成果:

纳米粒子有助于基因传递,人工抗原呈现细胞工程和免疫微环境重塑.
微球/微斑增强免疫细胞扩张,向激活和局部保留.
水凝支持现场基因工程,3D细胞培养和细胞因子联合递送,改善了ACT结果.

结论:

生物材料提供了多功能解决方案,通过提高输送效率,放大抗瘤反应和减轻毒性来增强固体瘤的ACT.
这些生物材料驱动的策略具有显著的潜力,可以加速ACT在治疗固体恶性瘤中的临床转化.

关键词:

收养细胞转移收养细胞转移生物材料是一种生物材料.化学抗原受体T细胞治疗药物交付是药物交付的过程.免疫细胞是免疫细胞.审查审查审查审查瘤微环境是一个微环境.

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