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早期代动态和静态质子弧治疗计划算法评估在口腔癌患者

Bas Adriaan De Jong¹, Lewei Zhao², Peilin Liu³

¹Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Medical physics

|July 15, 2025

概括

与强度调节质子疗法 (IMPT) 和VMAT相比,质子弧治疗 (PAT) 显著降低了口腔癌的毒性和治疗时间. 动态PAT交付速度比静态PAT快,范围变换器提高了稳定性.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
癌症治疗治疗癌症治疗

背景情况:

质子弧治疗 (PAT) 使用的门架角度比强度调制质子疗法 (IMPT) 更多,可能降低口腔癌 (OPC) 的健康组织剂量.
PAT算法可以是静态或动态的,但目标覆盖率可能对患者变化不如IMPT那么强大.

研究的目的:

评估静态和动态PAT规划算法是否改善了OPC患者的毒性,输送时间和稳定性,而不是体积调制弧线疗法 (VMAT) 和IMPT.

主要方法:

六名OPC患者使用能量层过 (ELF),点扫描质子弧 (SPArc) 和早期层和点分配 (ELSA) 算法接受了PAT计划.
正常组织并发症概率 (NTCP) 模型评估了毒性;模拟了分娩时间;使用重复的CT扫描评估了分数间的稳定性.

主要成果:

与IMPT和VMAT相比,所有PAT策略都显著降低了NTCP的功能障碍和异口症.
动态PAT计划 (SPArc,ELSA) 的交付时间比IMPT和静态PAT (ELF) 短.
在PAT中,分数智能目标覆盖率不如IMPT那么强大,但通道智能覆盖率受到影响较小;范围转换器提高了ELF计划的稳定性.

结论:

静态和动态PAT策略提供了与IMPT和VMAT相比的NTCP显著减少.
据估计,PAT的交付时间比目前的IMPT要短,动态PAT比静态PAT快.
虽然分数智能稳定性是一个问题,但航向智能稳定性受到影响较小,范围变换器可以增强PAT稳定性.

关键词:

交付时间交付时间动态和静态的PAT.正常组织并发症概率 (NTCP)这是口腔喉癌.进行质子处理.强度坚固性坚固性

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