动脉瘤壁增强和系统性炎症共同导致未经治疗的未破裂的内动脉瘤患者的认知功能障碍
Xiao-Bing Wu1, Bin Luo2, Xin Guo2
1Department of Neurosurgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Journal of inflammation research
|July 15, 2025
概括
未破裂的内动脉瘤患者表现出与全身炎症和动脉瘤壁增强相关的认知衰退. 年龄,血管炎症和白质变化是这种衰退的关键预测因素.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 未破裂的内动脉瘤 (UIAs) 可能涉及炎症,可能影响大脑功能.
- 在MRI上动脉瘤壁增强 (AWE) 和外周炎症标志物是这种炎症的指标.
研究的目的:
- 评估UIA患者的认知功能.
- 研究UIA患者的认知功能,全身炎症和放射性标志物之间的关联.
主要方法:
- 120名UIA患者和27名对照人进行了神经心理测试 (MMSE,MoCA,HAMA,SDS).
- 分析了周围炎症标志物 (NLR,SII,hs-CRP) 和HR-VWI发现 (AWE,WMH).
- 认知衰退被定义为一个MoCA得分<23.
主要成果:
- 与对照组相比,UIA患者的认知表现较差 (MMSE,MoCA较低).
- 认知能力下降与年龄增长,炎症标志物 (NLR,SII,hs-CRP) 升高以及AWE和白质超强度 (WMH) 的更高率有关.
- AWE,WMH和年龄是认知能力下降的独立预测因素 (P<0.01).
结论:
- 未经治疗的UIA与认知能力下降有关,与全身炎症有关.
- 血管炎症,由AWE和WMH表示,似乎有助于UIA患者的认知功能障碍.
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