快速歧视高度前列腺癌使用无标签的光终身测量
Julien Bec1, Xiangnan Zhou1, Yash Tipirneni1
1Department of Biomedical Engineering, University of California, Davis, CA, USA.
medRxiv : the preprint server for health sciences
|July 15, 2025
概括
无标签的光终身成像 (FLIm) 显示了前列腺癌 (PCa) 活检实时指导的前景. 这种技术可以有效地区分高档PCa与良性组织,提高诊断准确度.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 前列腺癌研究 研究前列腺癌
背景情况:
- 前列腺针活检的组织学评估对于癌症的诊断和治疗至关重要.
- 目前的活检向方法有局限性,即使有MRI指导.
- 需要新的技术来提高前列腺组织采样的准确性.
研究的目的:
- 调查无标签光终身成像 (FLIm) 在前列腺活检期间实时指导的有效性.
- 评估FLIm在区分恶性和良性前列腺组织方面的能力.
- 评估FLIm在改善前列腺癌诊断方面的潜力.
主要方法:
- 20名接受前列腺活检的患者被纳入了这项试点研究.
- 光终身成像 (FLIm) 测量是在使用光纤探头对活检样本进行的.
- 提取和分析光学参数以区分组织类型并训练恶性瘤分类器.
主要成果:
- FLIm成功地将良性组织与格里森等级≥4前列腺癌 (PCa) 分离,仅使用两个参数.
- 一个支持矢量机器分类器在识别4级PCa时获得了0.88的ROC.
- 降低的NADH生命周期值与恶性组织中糖解的增加相关,为差异化提供了生物化学基础.
结论:
- 光终身成像 (FLIm) 显示出识别高度前列腺癌的巨大潜力.
- 单纤维方法是最少的侵入性和适应性,可以集成到现有的活检工具.
- FLIm显示了改善前列腺活检程序的临床翻译的可行性.
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