性差异对陶病理的脆弱性:对认知衰退的影响
Yashar Zeighami1,2, Cecilia Tremblay1,2, Mahsa Dadar1,2
1Department of Psychiatry, McGill University.
medRxiv : the preprint server for health sciences
|July 15, 2025
概括
性差异影响阿尔茨海默病的进展. 患有粉样质斑块但没有tau病理的男性的衰退速度更快,而患有粉样质和tau的女性的衰退速度更快,突出了性别特定的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 已知粉样质斑块,团,神经退行和衰老中的认知衰退之间的关系.
- 然而,对这些病理的敏感性基于性别的差异仍然不太了解.
研究的目的:
- 调查与粉样蛋白和蛋白病理相关的认知衰退轨迹中的性别差异.
- 探索性如何影响粉样蛋白,蛋白和神经退行症在认知衰老中的相互作用.
主要方法:
- 利用了来自国家阿尔茨海默氏症协调中心 (NACC) 数据库的1,464名参与者的数据,并进行了7,168次纵向评估.
- 采用纵向混合效应和调解模型来分析与粉样蛋白 (A), (T) 和神经退行 (N) 标志物相关的认知衰退的性别差异.
主要成果:
- 患有粉样质斑块但没有tau病理的男性 (A+T-) 表现出比女性更快的认知衰退 (p<0.005).
- 与男性相比,患有粉样蛋白和蛋白病理 (A+T+) 的女性表现出更急剧的认知衰退 (p<0.0001).
- 性别显著调节了陶在粉样蛋白和认知衰退之间的关联中的调解作用 (p=0.046).
结论:
- 对病理的性别特异性脆弱性,特别是粉样蛋白存在时,显著影响认知衰退轨迹.
- 这些发现强调了将性别视为生物学变量在理解阿尔茨海默氏症病原和进展方面的重要性.
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