探索口腔健康和疫苗接种对引起肺炎的细菌的影响:从预测模型的洞察力
Ryann N Whealy1,2, Skylar Timm1,2, Tara N Furstenau2
1Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, United States of America.
口腔卫生有效地减少了养老院中的特定细菌,但并非所有病原体. 肺炎球菌疫苗接种也降低了殖民,这表明需要针对基于病原体储存库的干预措施.
科学领域:
- 老年学是指老年学的学科.
- 传染性疾病 传染性疾病
- 口腔健康 口腔健康
背景情况:
- 养老院获得的肺炎 (NHAP) 是长期护理设施 (LTCF) 中的主要死亡原因.
- 机会性病原体从口腔和鼻腔的宏观吸收是老年人的主要感染途径.
- 肺炎球菌疫苗接种是标准的,但口腔卫生在减少病原体殖民中的作用正在研究中,结果各不相同.
研究的目的:
- 调查口腔卫生和肺炎球菌疫苗接种如何影响特定的NHAP相关病原体的携带.
- 为了确定病原体的定居点 (口腔与前鼻腔) 是否影响干预的有效性.
主要方法:
- 分析口腔健康调查数据,肺炎球菌疫苗接种状态和纵向病原体殖民.
- 基于初级殖民地的病原体的分类.
主要成果:
- 口腔卫生干预措施减少了Hemophilus influenzae和Streptococcus pneumoniae的携带,它们主要殖民于口腔.
- 口腔卫生对黄金葡萄球菌和空气真菌菌菌的影响最小,在前鼻中普遍存在.
- 肺炎球菌疫苗接种减少了两种S.S.的殖民化. 肺炎 和H.肺炎 和H.肺炎 是一种疾病. 流感是一种流感.
结论:
- 口腔卫生干预措施对源自口腔的病原体最有效.
- 针对基于NHAP相关病原体的主要储存库的干预措施是有效预防的关键.
- 社区层面的相互作用可能解释了疫苗对多种病原体的影响.
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